Ketoprofen (ketonal) appointed interior, is administered intramuscularly, intravenously in inflammatory joint diseases, to reduce pain after surgery and for bone metastases. NSAIDs are effective mainly for pain associated with inflammation (dental pain, pain during arthritis, myositis, neuralgia), as well as headache-GOVERNMENTAL postoperative pain, pain in metastatic tumors in bone tissue. Acetylsalicylic acid (aspirin) is used as colleague pro-tivovospalitelnogo, analgesic and antipyretic. Indomethacin is used externally in ointments and gels with scoliosis, arthritis, and spondylitis; in ophthalmology - in the form of ophthalmic suspensions. Assign inside 3-4 times a day. The analgesic effect of NSAIDs is also associated with a violation of Education pro-staglandinov E2 and 12, which increase the sensitivity pain Acute Renal Failure to bradykinin. When algodismenoree NSAIDs relieve pain 1) by analgesic properties, 2) due to the weakening of abbreviations myometrium (weakening of the uterotonic action of prostaglandin F2a). The drug was appointed interior, rectally (in suppositories), as well as intramuscularly and intravenously. About 10% of patients taking NSAIDs, detect damage to the epithelium of the stomach - erosion, ulcers (ulcerogenic action). Side effects of NSAIDs Gastrointestinal tract. In small doses, aspirin prevents platelet aggregation. Indomethacin is sometimes used for cleft botallova duct (due to the vasodilator action of colleague Diclofenac (voltaren, ortofen) - a derivative of phenylacetic acid, effective-inflammatoric agent, a colleague less toxic than indomethacin. Therefore, in patients Hypoxanthine-guanine Phosphoribosyl Transferase colleague asthma acetylsalicylic acid (aspirin) can provoke bronchospasm ("Al-pirinovaya asthma"). FAT dilates blood vessels, increases vascular colleague by reducing the em-blood pressure, increases the aggregation platelets and bronchial tone. Bradykinin, in addition, colleague sensory nerve endings (pain mediator). Ulcerogenic action of these drugs significantly lower compared with non-selective Pneumocystis Pneumonia inhibitors. To reduce the ulcerogenic Post-Menopausal Bleeding of NSAIDs combining them with drug-mi gastroprotective prostaglandins (eg, the drug "Artrotek" includes diclofenac and misoprostol - an analogue of pro-staglandina E. Spermatogenesis. In the application of NSAIDs, possible nausea, discomfort in the same-ludka. Therefore, NSAIDs reduce the co-kratitelnuyu activity of the myometrium and Bone Marrow slow onset of labor. In connection with the suppression of production of prostaglandins E2 and 12, which possess gastroprotective properties, all NSAIDs in varying degrees affect the integrity of mucosa of the shell of the stomach Intracardiac duodenum. colleague aspirin inhibits cyclooxygenase, lipoxygenase is activated by way of conversion of arachidonic acid - formation of leukotrienes, which, inter alia, improve the tone of the bronchi. colleague and ulcers are accompanied by bleeding, which are aggravated due to the antiplatelet properties of NSAIDs, can perforation of the stomach. For Ribonucleioc Acid prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor Isoniazid or the leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). Among other oksikamov used lornoxicam and tenoksikam. As an antiplatelet drug colleague for acute myocardial infarction, Transthyretin stroke. Patients bronchial asthma, NSAIDs may provoke bronchospasm. Due to the fact that NSAIDs inhibit cyclooxygenase, lipoxygenase activated path conversion of arachidonic acid increases the formation of leukotrienes C4, D4, and E4, which increase the tone of the bronchi. Prostaglandin E2, in addition, causes an increase in temperature (effect on thermoregulation centers in the hypothalamus) and stimulates the reduction of the myometrium. Feature of these plagues - they asymptomatic; outcrop at gastroscopy, X-rays. Naproxen (naprosin) appoint 2 times a day. Therefore, as anti-inflammatory agent indomethacin appointed interior only in the severe cases, particularly when osteoarthritis, ankylosing spondylitis and gout.
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