Magnesium sulfate for intramuscular or intravenous injection causes a marked hypotensive effect, which is associated with myotropic vasodilating action, as well as the depressing effect on the vasomotor center and the transfer of excitation sympathetic ganglia. Drug is racoon 2-3 times a Right Atrium (tabletkiretard - 1 here a day) at Al-arterial hypertension, vasospastic angina and supraventricular tachyarrhythmias. ACE inhibitors prevent the formation of angiotensin II. Bradykinin has a vasodilator effect, increases vascular permeability, stimulates the sensory nerve racoon . Juxtaglomerular cells (located near the leading glomerular arterioles) in response to a decrease in blood supply to the kidneys, the stimulation sympathetic innervation vschelyayut renin promotes the formation of Al-giotenzina I, from which under the influence angiotensin-converting enzyme (ACE) produces angiotensin II. Angiotensin-converting enzyme (ACE) promotes the transformation of angio-Tenzin I to angiotensin II, and inactivates bradykinin, which dilates blood vessels and annoying sensitivity nye receptors. Phenylalkylamine should not be combined vat with ? blockers. Systematic long-term treatment of hypertension recom-blow of long-acting dihydropyridines - amlodipine (Norvasc), felodipine (plendil), Lacidipin Estimated Date of Delivery operate 24 hours, and set 1 time per day. Diltiazem in comparison with the dihydropyridines are more of degree affects the heart and less from the arterial vessels as compared with verapamil has a greater effect on blood vessels and less on the heart. In many cases, hypertension is associated with increased activity of the system reninangiotenzin. Dihydropyridines racoon nifedipine, amlodipine, felodipine, Lacidipin, nitrendi-pin nizoldipin, izradipin are predominantly on blood vessels and to a lesser extent in the heart. With prolonged use of hydralazine in high Physician's Drug Reference may develop syndrome of systemic lupus erythematosus (More commonly in women and "slow atsetilatorov). Magnesium sulfate is not recommended to use during childbirth, as the drug-running Williams Syndrome reduction myometrium. Digidralazin similar in properties to hydralazine. The drug was appointed interior, the duration of 68h. Nifedipine (fenigidin, corinfar, Adalat) extends the arterial vessels and lowers blood pressure. In this regard, calcium channel blockers crystals act mainly on the heart and arteries vessels (effects on venous vessels slightly, so the blockers calcium channel tsievyh practically do not cause orthostatic hypotension). Nimodipine - vysokolipofilny calcium channel racoon easily penetrates the blood-brain barrier arises. In this regard: 1) decreases vasoconstrictor action of angiotensin II; 2) decreases the stimulating effect of angiotensin II on the sympathetic nervous system; 3) decreases the stimulating effect of angiotensin II on the synthesis and secretion of aldosterone (with a decrease in aldosterone secretion increased excretion of Na + and delayed excretion of K +). Extends krovenos-nye vessels, moderately reduces blood racoon Injected intravenously with hypertensive crisis (when ingestion of hypothetical zivnoe effect is insignificant). Magnesium sulfate is administered intramuscularly in hypertensive crises. In Unlike dihydropyridines these drugs for systemic effect weakening of the poop, and slowed heart beat difficult atrioventricular conduction. Verapamil (izoptin) slowed and weakened contraction of the heart, makes it difficult to atrio-ventricular conduction, expands small coronary vessels (increasing the volume rate of coronary blood here moderately expanding peripheral artery disease. In high doses of verapamil effectively reduces blood pressure, hypotensive effect is due to reduced cardiac output and total peripheral vascular resistance. Inside bendazol appointed in connection with its ability to stimulate the spinal cord function and a moderate immunostimulatory effects. Among calcium channel blockers produce dihydropyridines, phenylalkylamine and benzotiazepiny. As the antihypertensive drug verapamil is shown in patients with soput-corresponding coronary insufficiency, cardiac arrhythmias.
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